Testosterone pellet implants have been found to be effective therapy in reducing the number and severity of migraine headaches in both pre-and postmenopausal women.
Migraine headaches are associated with hormonal changes in females. A pilot study was designed to determine the effect of continuous testosterone, delivered by subcutaneous implant, on migraine headache severity in pre- and post-menopausal women. Testosterone has wide ranging biological effects in pre- and postmenopausal women, in part because of widespread androgen receptors found in brain, spinal cord, nerves, breast, bone, muscles, cardio-vascular system, lungs, GI tract, bladder, vaginal tissue, uterus, skin, hair follicles and adipose tissue. Testosterone can also exert its effect indirectly via aromatization to estrogen and by production in the ovary and adrenal glands.
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